Diastolic dysfunction and left atrial volume
A population-based study
Allison M. Pritchett, MD*,
Douglas W. Mahoney, MS ,
Steven J. Jacobsen, MD, PhD ,
Richard J. Rodeheffer, MD, FACC*,
Barry L. Karon, MD, FACC* and
Margaret M. Redfield, MD, FACC*,*
* Division of Cardiovascular Diseases, Department of Internal Medicine and the Divisions of
Clinical Epidemiology
Biostatistics, Department of Health Science Research, Mayo Clinic College of Medicine, Rochester, Minnesota
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Figure 1 Stepwise multivariate analysis demonstrating the cumulative effect of age, gender, cardiovascular (CV) disease (dis), ejection fraction (EF), left ventricular mass index (LVMi), and diastolic dysfunction (DD) on left atrial volume index (LAVi) in the population. In the left panel, CV, EF and LVMi, and DD all add to the base model of age and gender for prediction of LAVi. In the middle panel, the addition of EF and LVMi as well as DD add to the base model of age, gender, and CV disease. In the right panel, the addition of DD adds to the base model incorporating age, gender, CV disease, EF and LVMi. *p < 0.001 compared with the base model.
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Figure 2 Kaplan-Meier survival curves demonstrating the relationships between severity of diastolic dysfunction (DD) (left) and left atrial (LA) volume index (right) and survival. Mod-sev = moderate to severe.
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