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Plasma leptin and prognosis in patients with established coronary atherosclerosis

Robert Wolk, MD, PhD^*,, Peter Berger, MD, FACC^*, Ryan J. Lennon, MS, Emmanouil S. Brilakis, MD^*, Bruce D. Johnson, PhD^* and Virend K. Somers, MD, PhD, FACC^*,,*

^* Cardiovascular Diseases
Hypertension
Biostatistics, Mayo Clinic, Rochester, MinnesotaUSA

View larger version (17K): [in a new window]   Figure 1 The cubic relationship between leptin levels and hazard ratios for the combined end point. The leptin value of 4 ng/ml was taken as reference. Leptin is plotted on a logarithmic scale.

View larger version (18K): [in a new window]   Figure 2 Association between leptin (determined by the sample quintiles) and hazard ratios for the combined end point. The bars indicate 95% confidence intervals. The reference level is the first quintile.

View larger version (18K): [in a new window]   Figure 3 Kaplan-Meier survival free of cardiac death, myocardial infarction, cerebrovascular accident, and revascularization for the leptin quintile groups. Note the truncated ordinate axis.