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Economic evaluation of bivalirudin with provisional glycoprotein IIB/IIIA inhibition versus heparin with routine glycoprotein IIB/IIIA inhibition for percutaneous coronary intervention

Results from the REPLACE-2 trial

David J. Cohen, MD, MSc^*,,*, A. Michael Lincoff, MD, Tara A. Lavelle, BS, Huei-Ling Chen, PhD, Ameet Bakhai, MD^*,, Ronna H. Berezin, MPH, Daniel Jackman, MD, Ian J. Sarembock, MB, ChB^|| and Eric J. Topol, MD

^* Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Harvard Clinical Research Institute, Brookline, Massachusetts, USA
Mother Frances Hospital, Tyler, Texas, USA
^|| Cardiovascular Division and Cardiovascular Research Center, University of Virginia Health System, Charlottesville, Virginia, USA
Cleveland Clinic Foundation, Cleveland, Ohio, USA

View larger version (21K): [in a new window]   Figure 1 Stratified analyses of aggregate 30-day costs by treatment group according to prespecified patient characteristics. The graph indicates the mean difference in costs between the bivalirudin + provisional glycoprotein (GP) IIb/IIIa and heparin + routine GP IIb/IIIa groups (black squares) along with the associated 95% confidence interval (bars). There was no evidence of heterogeneity of treatment effect across any of the subgroups (p value for interaction >0.05).