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J Am Coll Cardiol, 2004; 44:1675-1678, doi:10.1016/j.jacc.2004.07.041
© 2004 by the American College of Cardiology Foundation
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Ephedrine increases ventricular arrhythmias in conscious dogs after myocardial infarction

Philip B. Adamson, MDFACC*,{dagger},*, Jennifer Suarez, BS*, Ethannah Ellis, BS*, Travis Kanaly, BS* and Emilio Vanoli, MD*,{dagger},{ddagger}

* Department of Physiology, Cardiovascular Diseases, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
{dagger} Department of Medicine, Cardiovascular Diseases, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
{ddagger} Dipartimento di Cardiologia, Policlinico San Matteo, IRCCS e Università di Pavia, Pavia, Italy



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Figure 1 Arrhythmia incidence during no-drug control (left), ephedrine treatment (middle), and drug washout (right). The 60% increase in arrhythmia incidence during ephedrine therapy was significant (p < 0.02). PVC = premature ventricular contractions; VF = ventricular fibrillation; VT = ventricular tachycardia.

 


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Figure 2 Serum catecholamine levels before (no drug; open bars) and after treatment with ephedrine (hatched bars). Epi = epinephrine; Norepi = norepinephrine; Total = total catecholamines. *p < 0.001.

 




 
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