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QT interval variability and spontaneous ventricular tachycardia or fibrillation in the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II patients

Mark C. Haigney, MD^*,*, Wojciech Zareba, MD, PhD, Philip J. Gentlesk, MD^*, Robert E. Goldstein, MD^*, Michael Illovsky, MD^*, Scott McNitt, PhD, Mark L. Andrews, PhD, Arthur J. Moss, MD the MADIT II Investigators

^* Division of Cardiology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland
Division of Cardiology, Department of Medicine, University of Rochester School of Medicine, Rochester, New York

View larger version (17K): [in a new window]   Figure 1 Cumulative probability of first appropriate defibrillator therapy for ventricular tachycardia (VT) or ventricular fibrillation (VF) in patients with QT variability (QTVN) in the highest quartile versus lower three quartiles for QT variability index (QTVI) (top panel) and QTVN (bottom panel). P value from log-rank statistics. ICD = implantable cardioverter defibrillator.

View larger version (21K): [in a new window]   Figure 2 Cumulative probability of first appropriate defibrillator therapy for ventricular tachycardia or fibrillation in patients with QT variability (QTVN) by quartile of QTVN. P value from log-rank statistics. ICD = implantable cardioverter defibrillator; VF = ventricular fibrillation; VT = ventricular tachycardia.

View larger version (15K): [in a new window]   Figure 3 Cumulative probability of first appropriate defibrillator therapy for ventricular tachycardia (VT) or ventricular fibrillation (VF) in patients without bundle branch block with QT variability (QTVN) in the highest quartile versus lower three quartiles. P value from log-rank statistics. ICD = implantable cardioverter defibrillator.

View larger version (15K): [in a new window]   Figure 4 Cumulative probability of survival in patients randomized to defibrillator implantation with QT variability (QTVN) in the highest quartile versus lower three quartiles for QT variability index (QTVI) (top panel) and QTVN (bottom panel). P value from log-rank statistics.