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Brachytherapy: Potential therapy for refractory coronary spasm

Paul Erne, MD^*,*, Peiman Jamshidi, MD^*, Peter Juelke, MD, Hans-Peter Hafner, PhD, Peter Thum, MD and Therese Resink, PhD

^* Cardiology
Radiotherapy, Kantonsspital Luzern, LuzernSwitzerland
Department of Research, Kantonsspital Basel, Basel, Switzerland

View larger version (19K): [in a new window]   Figure 1 Brachytherapy reduces acetylcholine (ACh)-induced vasoconstriction. Individual vessel diameter changes (with median values) after infusion with ACh before and after brachytherapy. Circles = first vessel and squares = second vessel before (open circles and open squares) and at follow-up after brachytherapy (solid circles and solid squares); second vessel in non-irradiated states at first investigation (open triangles) and follow-up after brachytherapy of first vessel (solid triangles). p indicates effect of brachytherapy.

View larger version (23K): [in a new window]   Figure 2 Brachytherapy reduces adenosine-induced changes in acceleration and deceleration time of flow velocities. Individual adenosine-induced changes (with median values) in acceleration (+dv/dt; upper panel) and deceleration (–dv/dt; lower panel) flow velocities before and after brachytherapy. Circles = first vessel and squares = second vessel before (open circles and open squares) and at follow-up after brachytherapy (solid circles and solid squares). Second vessel in non-irradiated states at both the first investigation (open triangles) and follow-up after brachytherapy of first vessel (solid triangles). p indicates effect of brachytherapy.

View larger version (12K): [in a new window]   Figure 3 Brachytherapy reduces the frequency of anginal episodes. Weekly frequency of anginal episodes for each patient before brachytherapy (open circles) and at follow-up (solid circles).