Serum levels of interleukin-10 on admission as a prognostic predictor of human fulminant myocarditis
Mototsugu Nishii, MD*,
Takayuki Inomata, PhD, MD,
Hitoshi Takehana, PhD, MD,
Ichiro Takeuchi, MD,
Hironari Nakano, MD,
Toshimi Koitabashi, MD,
Jun-ichi Nakahata, MD,
Naoyoshi Aoyama, PhD, MD and
Tohru Izumi, PhD, MD
Department of Internal Medicine and Cardiology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
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Figure 1 (A) Comparison of serum levels of interleukin (IL)-10 and tumor necrosis factor (TNF)-alpha on admission between non-survivors and survivors in fulminant myocarditis. Serum levels of IL-10, but not TNF-alpha, on admission increased considerably in five non-survivors when compared with levels in nine survivors of fulminant myocarditis with cardiogenic shock requiring mechanical circulatory support. (B) Comparison of serum levels of IL-10 on admission between non-survivors and survivors in acute myocardial infarction. Serum levels of IL-10 on admission slightly increased in 5 non-survivors when compared with levels in 10 survivors of acute myocardial infarction with cardiogenic shock requiring mechanical circulatory support. Solid bars and closed circles = mean ± SEM; Open circles = data of subjects in the present study. AMI = acute myocardial infarction; FMC = fulminant myocarditis.
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