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Reduced incidence of hypertension after heterotopic cardiac transplantation compared with orthotopic cardiac transplantation

Evidence that excision of the native heart contributes to post-transplant hypertension

Anne B. Taegtmeyer, BMBCH^*,, Angela M. Crook, MSC, Paul J.R. Barton, PHD and Nicholas R. Banner, FRCP^*,*

^* Transplant Unit, Harefield Hospital, Harefield, United Kingdom
Heart Science Centre, Harefield Hospital, Harefield, United Kingdom
Department of Public Health Research, Westminster Primary Care Trust, London, United Kingdom

View larger version (9K): [in a new window]   Figure 1 Survival beyond three months and up until five years in orthotopic cardiac transplantation (OCT) and heterotopic heart transplantation (HHT) patients studied; log-rank test p = 0.044.

View larger version (13K): [in a new window]   Figure 2 Systolic blood pressure in orthotopic cardiac transplantation (OCT) and heterotopic heart transplantation (HHT) patients three months post-transplantation. Figures and lines are means ± SD.

View larger version (18K): [in a new window]   Figure 3 Proportion of orthotopic cardiac transplantation (OCT) and heterotopic heart transplantation (HHT) patients with systolic blood pressure (SBP) 140 mm Hg (or receiving antihypertensive treatment) over time, p = 0.001. Figures are numbers at risk (number of events).

View larger version (14K): [in a new window]   Figure 4 Systolic blood pressure in two patients who underwent heterotopic heart transplantation (HHT) followed by orthotopic cardiac transplantation (OCT). (A) 32-year-old man; (B) 45-year-old man. *Introduction of antihypertensive agents.