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Vascular complications associated with arteriotomy closure devices in patients undergoing percutaneous coronary procedures

A meta-analysis

Eugenia Nikolsky, MD, PhD^*, Roxana Mehran, MD, FACC^*, Amir Halkin, MD^*, Eve D. Aymong, MD, FACC^*, Gary S. Mintz, MD, FACC^*, Zoran Lasic, MD, FACC^*, Manuela Negoita, MD^*, Martin Fahy, MSc^*, Shoshana Krieger, BA^*, Issam Moussa, MD, FACC^*, Jeffrey W. Moses, MD, FACC^*, Gregg W. Stone, MD, FACC^*, Martin B. Leon, MD, FACC^*, Stuart J. Pocock, PhD and George Dangas, MD, PhD, FACC^*,*

^* Cardiovascular Research Foundation and the Lenox Hill Heart and Vascular Institute, New York, New York, USA
London School of Hygiene and Tropical Medicine, London, United Kingdom

View larger version (33K): [in a new window]   Figure 1 Odds ratio (OR) and 95% confidence interval (CI) of vascular access-related complication rate in patients with Angio-Seal and mechanical compression (control) in diagnostic (Dx), percutaneous coronary intervention (PCI), mixed (Dx+PCI), or any setting. RCT = randomized controlled trials. *Fixed effects model; random effects model.

View larger version (33K): [in a new window]   Figure 2 Odds ratio (OR) and 95% confidence interval (CI) of vascular access-related complication rate in patients with VasoSeal and mechanical compression (control) in diagnostic (Dx), percutaneous coronary intervention (PCI), mixed, or any setting. *Fixed effects model. RCT = randomized controlled trials.

View larger version (43K): [in a new window]   Figure 3 Odds ratio (OR) and 95% confidence interval (CI) of vascular access-related complication rate in patients with Perclose and mechanical compression (control) in diagnostic (Dx), percutaneous coronary intervention (PCI), mixed, or any setting. *Fixed effects model; random effects model. RCT = randomized controlled trials.

View larger version (17K): [in a new window]   Figure 4 Odds ratio (OR) and 95% confidence interval (CI) of vascular access-related complication rate in patients with any arteriotomy closure device (ACD) and mechanical compression (control) in diagnostic (Dx), percutaneous coronary intervention (PCI), mixed, or any setting. Diamonds = all studies; squares = randomized studies.