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Stroke prevention with the angiotensin II type 1-receptor blocker candesartan in elderly patients with isolated systolic hypertension

The study on cognition and prognosis in the elderly (SCOPE)

Vasilios Papademetriou, MD^*,*, Csaba Farsang, MD, Dag Elmfeldt, MD^,, Albert Hofman, MD^||, Hans Lithell, MD, Bertil Olofsson, MD, Ingmar Skoog, MD^¶, Peter Trenkwalder, MD^#, Alberto Zanchetti, MD^** for the SCOPE Study Group

^* Hypertension and Cardiovascular Research, Veterans Administration Medical Center, Washington, DC, USA
First Department of Internal Medicine St. Emeric Teaching Hospital, Budapest, Hungary
Department of Public Health and Caring Sciences, Sections of Geriatrics, Clinical Hypertension Research and Family Medicine, University of Uppsala, Uppsala, Sweden
^|| Departments of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, the Netherlands
Clinical Science, Medicine and Biostatistics, AstraZeneca R&D, Mölndal, Sweden
^¶ Institute of Clinical Neurosciences, Neuropsychiatric Epidemiology Unit, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden
^# Department of Internal Medicine, Starnberg Hospital, Ludwig Maximilian University Munich, Starnberg, Germany
^** Centro di Fisiologia Clinica e Ipertensione, University of Milan and Istituto Auxologico Italiano, Milan, Italy

View larger version (16K): [in a new window]   Figure 1 Systolic and diastolic blood pressure during the study. Solid lines = control group; dashed lines = candesartan group. LVCF = last value carried forward.

View larger version (18K): [in a new window]   Figure 2 Kaplan-Meier curves for all stroke (fatal or non-fatal).