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Evaluation of cardioprotective effects of recombinant soluble P-selectin glycoprotein ligand-immunoglobulin in myocardial ischemia-reperfusion injury by real-time myocardial contrast echocardiography

Alexander Hansen, MD^,*, Anjali Kumar, PhD^*, David Wolf, BS, Kamilla Frankenbergerova, BS, Arthur Filusch, MD, Marie-Luise Gross, MD, Sebastian Mueller, MD, Hugo Katus, MD and Helmut Kuecherer, MD

^* Wyeth Research, Cambridge, Massachusetts, USA
Cardiology
Pathology, University of Heidelberg, Heidelberg, Germany

View larger version (119K): [in a new window]   Figure 1 Real-time myocardial contrast echocardiography with reappearance of myocardial contrast after bubble destruction ("flash"). Transmural myocardial infarction after 120-min reperfusion, with complete loss of contrast enhancement in the risk area (a to c). Hyperemic reflow during early reperfusion after temporary ischemia with contrast enhancement appears first in the left anterior descending coronary artery perfusion territory (d to f).

View larger version (21K): [in a new window]   Figure 2 Time course in the perfusion defect size to risk area by myocardial contrast echocardiography (MCE) (top). *p < 0.05 for comparisons between vehicle (solid lines) and recombinant P-selectin glycoprotein ligand-immunoglobulin (rPSGL-Ig) (dashed lines). Correlation between the perfusion defect size to risk area by MCE at 120-min reperfusion and the infarct size to risk area of the corresponding myocardial slice by TTC staining (bottom) in the rPSGL-Ig (circles) and vehicle (squares) groups.

View larger version (23K): [in a new window]   Figure 3 Quantitative myocardial contrast echocardiography parameters A (top), ß (middle), and A x ß (bottom) in the left anterior descending coronary artery (LAD) territories at baseline (bas), during LAD occlusion (occ), and reperfusion. The decrease in indexes of myocardial perfusion during reperfusion was lower in the recombinant P-selectin glycoprotein ligand-immunoglobulin (rPSGL-Ig) group (dashed lines) than in the vehicle group (solid lines). *p < 0.05.