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J Am Coll Cardiol, 2004; 44:588-593, doi:10.1016/j.jacc.2004.04.038
© 2004 by the American College of Cardiology Foundation
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Sublingual nitroglycerin used in routine tilt testing provokes a cardiac output-mediated vasovagal response

Janneke Gisolf, MSc*,*, Berend E. Westerhof, MSc{dagger}, Nynke van Dijk, MD{ddagger}, Karel H. Wesseling, MSc§, Wouter Wieling, MD, PhD{ddagger} and John M. Karemaker, PhD*

* Department of Physiology, Academic Medical Center, Cardiovascular Research Institute, AmsterdamNetherlands
{dagger} TNO-TPD-BMI, Academic Medical Center, Cardiovascular Research Institute, AmsterdamNetherlands
{ddagger} Department of Internal Medicine, Academic Medical Center, Cardiovascular Research Institute, Amsterdam, Netherlands
§ Finapres Medical Systems, Amsterdam, the Netherlands



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  		Figure 1 Hemodynamic response to NTG during the 60° tilt test. At 0 min, nitroglycerine is administered. (A) mean arterial pressure (MAP); (B) stroke volume (SV); (C) cardiac output (CO); (D) systemic vascular resistance (SVR); (E) heart rate (HR); (F) baroreflex sensitivity (BRS). Circles = minute averages and SEM. Open circles = negative tilt test; solid circles = positive tilt test.

 


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  		Figure 2 Computed trends of minute averages over 4 min immediately after nitroglycerine administration during 60° tilt test. (A) Slope of heart rate; (B) Slope of stroke volume. Open circles = negative tilt test; solid circles = positive tilt test. Bars indicate SEM.

 




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