Intracoronary brachytherapy after stenting de novo lesions in diabetic patients
Results of a randomized intravascular ultrasound study
Manel Sabaté, MD*,*,
Gela Pimentel, MD*,
Carlos Prieto, BSc*,
JoséMaría Corral, MD*,
Camino Bañuelos, MD*,
Dominick J. Angiolillo, MD*,
Fernando Alfonso, MD*,
Rosana Hernández-Antolín, MD*,
Javier Escaned, MD*,
Panayotis Fantidis, MD*,
Cristina Fernández, MD*,
Antonio Fernández-Ortiz, MD*,
Raúl Moreno, MD* and
Carlos Macaya, MD*
* San Carlos University Hospital, Madrid, Spain
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Figure 1 Cross-sectional (A and A') and longitudinal (B and B') intravascular ultrasound images of a coronary segment immediately after treatment and at follow-up. Luminal, plaque, and total vessel function curves are represented in the bottom charts (C and C'). In this example, a marked increment of intra-stent neointimal hyperplasia is shown.
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Figure 2 Change in total vessel volume (TVV), plaque volume (PV), and luminal volume (LV) at the stented segment from post-treatment to follow-up between groups. Open bars = control group; shaded bars = brachytherapy group.
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Figure 3 Absolute reduction in restenosis rates in the four prespecified coronary segments between groups. Open bars = control group; shaded bars = brachytherapy group.
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Figure 4 Cumulative frequency distribution curves of MLD between groups at the target segment. By comparison, using the Student t test, the mean MLD at follow-up (F/U) became significant between groups (p > 0.0001).
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Figure 5 Cumulative frequency distribution curves of minimal luminal diameter between groups at the vessel segment. By comparison, using the Student t test, the mean minimal luminal diameter at follow-up (F/U) was no longer significant between groups.
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