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Improved outcomes of pediatric dilated cardiomyopathy with utilization of heart transplantation

Anna E. Tsirka, MD^*, Kathryn Trinkaus, PhD, Su-Chiung Chen, MD, Steven E. Lipshultz, MD, Jeffrey A. Towbin, MD, FACC^||, Steven D. Colan, MD, FACC^¶, Vernat Exil, MD^#, Arnold W. Strauss, MD, FACC^# and Charles E. Canter, MD, FACC^*,*

^* Department of Pediatrics, St. Louis, Missouri, USA
Department of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA
Department of Pediatrics, St. Louis University School of Medicine, St. Louis, Missouri, USA
Department of Pediatrics, University of Miami School of Medicine, Miami, Florida, USA
^|| Department of Pediatrics, Baylor University School of Medicine, Houston, Texas, USA
^¶ Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
^# Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

View larger version (22K): [in a new window]   Figure 1 Time to outcome after presentation among 91 children with dilated cardiomyopathy. The percentage of patients with a given outcome (transplantation, recovery, or death) is shown as a function of year of follow-up. Patients are censored from ongoing follow-up once they have undergone transplantation, died, or had recovery of left ventricular systolic function. Thus, the figure represents new outcomes that occurred in the cardiomyopathy patients available for follow-up at the given time interval.

View larger version (13K): [in a new window]   Figure 2 Overall survival for 91 children with dilated cardiomyopathy (95% confidence bands are shown). Last follow-up times are indicated by "+" for patients alive at the end of the study.

View larger version (16K): [in a new window]   Figure 3 Freedom from "heart death" (death or heart transplantation) in 91 children with dilated cardiomyopathy (95% confidence bands are shown). Last follow-up times are indicated by "+" for patients alive at the end of the study.