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B-type natriuretic peptide at presentation and prognosis in patients with ST-segment elevation myocardial infarction

An ENTIRE–TIMI-23 substudy

Jessica L. Mega, MD^*, David A. Morrow, MD, MPH, FACC^*,*, James A. de Lemos, MD, FACC, Marc S. Sabatine, MD, MPH^*, Sabina A. Murphy, MPH^*, Nader Rifai, PhD, C. Michael Gibson, MD, FACC^*, Elliott M. Antman, MD, FACC^* and Eugene Braunwald, MD, FACC^*

^* TIMI Study Group, Boston, Massachusetts 02115, USA
Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, USA
University of Texas Southwestern Medical Center, Dallas, Texas, USA
Children's Hospital, Boston, Massachusetts, USA

View larger version (15K): [in a new window]   Figure 1 Relationship between elevated biomarkers and mortality at 30 days. Positive results (solid bars) were defined as B-type natriuretic peptide (BNP) >80 pg/ml, cardiac troponin 0.1 ng/ml, and high sensitivity C-reactive protein (CRP) 15 mg/l (negative results = open bars).

View larger version (16K): [in a new window]   Figure 2 Probability of death through 30 days stratified by B-type natriuretic peptide (BNP).

View larger version (11K): [in a new window]   Figure 3 The receiver-operator characteristic curve for B-type natriuretic peptide at 10-pg/ml intervals for predicting death at 30 days.

View larger version (20K): [in a new window]   Figure 4 Association of B-type natriuretic peptide (BNP), in conjunction with cardiac troponin and high sensitivity C-reactive protein (CRP), with mortality at 30 days. Positive results (solid bars) were defined as BNP >80 pg/ml, cardiac troponin 0.1 ng/ml, and high sensitivity CRP 15 mg/l (negative results = open bars).