Impact of beta-myosin heavy chain expression on cardiac function during stress
Maike Krenz, MD and
Jeffrey Robbins, PhD*
Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
View larger version (36K):
[in a new window]
|
Figure 1 Echocardiographic assessment of left ventricular (LV) function after coronary ligation. Solid bars = nontransgenic (NTG); open bars = transgenic (TG). *p < 0.05 TG versus NTG.  p < 0.05 infarct group versus respective sham group (n = 11 in NTG infarct group; n = 10 in TG infarct group; n = 10 in NTG sham group; n = 8 in TG sham group).
|
|
View larger version (15K):
[in a new window]
|
Figure 3 (A) Exercise capacity on the treadmill of transgenic (TG) (open squares) and nontransgenic (NTG) (solid circles) mice at the end of the four-week swim training. (B) Ratio of left ventricular (LV) weight to body weight after four weeks in exercised and non-exercised groups. Solid bars = NTG; open bars = TG. *p < 0.05 versus respective non-exercised group (n = 4 to 6 in each group).
|
|
View larger version (28K):
[in a new window]
|
Figure 4 Left ventricular (LV) function and chamber dimensions before and after swim training, as assessed by echocardiography. Solid bars = nontransgenic (NTG); open bars = transgenic (TG). *p < 0.05 before versus after swim training (n = 5 or 6 in each group).
|
|
View larger version (19K):
[in a new window]
|
Figure 5 Hemodynamic parameters under acute dobutamine challenge in increasing doses in the intact, closed-chest animal. (A) Left ventricular systolic peak pressure (LVP). (B) Maxima of the first derivative of left ventricular pressure (dP/dtmax). Solid squares = nontransgenic (NTG); open squares = transgenic (TG). *p < 0.05 TG versus NTG (n = 4 or 5 per group).
|
|
|
p < 0.05 24 h versus 2 weeks (n = 8 to 12). (C) Hematoxylin-eosin–stained 5-µm sections of lung tissue. Note perivascular edema and engorged alveolar capillaries filled with erythrocytes in the TG lung (arrows).