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Comparative accuracy of real-time myocardial contrast perfusion imaging and wall motion analysis during dobutamine stress echocardiography for the diagnosis of coronary artery disease

Abdou Elhendy, MD, PhD, FACC^*, Edward L. O'Leary, MD, FACC^*, Feng Xie, MD^*, Anna C. McGrain, BSN, RN^*, James R. Anderson, PhD and Thomas R. Porter, MD, FACC^*,*

^* Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska
Department of Biostatistics, University of Nebraska Medical Center, Omaha, Nebraska

View larger version (66K): [in a new window]   Figure 1 Echocardiographic images from the apical four-chamber and three-chamber views, at rest, intermediate stage (Intm), and peak stage of dobutamine stress in a patient with left anterior descending (LAD) and left circumflex (LCx) coronary artery disease (CAD). Perfusion abnormalities were evident in the lateral, posterior, and apical segments at intermediate phase with extension of these abnormalities at peak stress (arrows). The patient had inducible wall motion abnormalities confined to the apex at peak stress.

View larger version (12K): [in a new window]   Figure 2 Pooled regional sensitivities of wall motion analysis and myocardial contrast echocardiography for the diagnosis of coronary stenoses between 50% and 69% and 70%. Solid bars = perfusion; open bars = wall motion.