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Heritability and correlates of intercellular adhesion molecule-1 in the Framingham Offspring Study

John F. Keaney, Jr, MD, FACC^*,*, Joseph M. Massaro, PhD^||, Martin G. Larson, ScD^||, Ramachandran S. Vasan, MD, FACC^*||, Peter W. F. Wilson, MD, FACC^*||, Izabella Lipinska, PhD, Diane Corey, BS^||, Patrice Sutherland, BS^||, Joseph A. Vita, MD, FACC^* and Emelia J. Benjamin, MD, ScM, FACC^*||

^* Evans Memorial Department of Medicine, Boston, Massachusetts, USA
Whitaker Cardiovascular Institute, Boston, Massachusetts, USA
Department of Preventive Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
Department of Epidemiology and Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
^|| National Heart, Lung, and Blood Institute's Framingham Study, Framingham, Massachusetts, USA

View larger version (24K): [in a new window]   Figure 1 Age-adjusted serum soluble intracellular adhesion molecule-1 (sICAM-1) in relation to Framingham Risk Score for subjects without prevalent cardiovascular disease. Age-adjusted serum sICAM-1 levels are plotted as a function of gender-specific quintile Framingham Risk Score for both men and women without prevalent cardiovascular disease. The gender- and age-adjusted relation between risk score and sICAM-1 was significant by multivariable linear regression (p < 0.001).

View larger version (15K): [in a new window]   Figure 2 Unadjusted serum soluble intracellular adhesion molecule-1 (sICAM-1) in relation to body mass index (BMI) in non-smokers. Serum sICAM-1 levels are plotted for non-smoking subjects grouped according to normal (18.5 to 24.9), overweight (25.0 to 29.9), or obese (30) BMI with the number of observations (N) given in each group. The relationship between sICAM-1 levels and BMI did not vary significantly by gender or smoking status and was significant by gender- and age-adjusted multivariable linear regression (p < 0.001).