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Doppler-derived mitral deceleration time as a strong prognostic marker of left ventricular remodeling and survival after acute myocardial infarction

Results of the GISSI-3 Echo substudy

Pier L. Temporelli, MD^*,*, Pantaleo Giannuzzi, MD^*, Gian L. Nicolosi, MD, Roberto Latini, MD, Maria G. Franzosi, PhD, Francesco Gentile, MD, Luigi Tavazzi, MD^||, Aldo P. Maggioni, MD^¶ GISSI-3 Echo Substudy Investigators

^* Fondazione Salvatore Maugeri, Istituto di Ricovero e Cura a Carattere Scientifico, Veruno, Italy
Ospedale Civile, Pordenone, Italy
Istituto di Ricerche Farmacologiche "Mario Negri," Milano, Italy
Ospedale Bassini, Cinisello Balsamo, Italy
^|| Ospedale S. Matteo, Pavia, Italy
^¶ Centro Studi ANMCO, Firenze, Italy

View larger version (21K): [in a new window]   Figure 1 Changes in end-diastolic volume index (EDVi) (A), end-systolic volume index (ESVi) (B), ejection fraction (EF) (C), and extent of wall motion abnormalities (%WMA) (D) during the follow-up in patients with baseline deceleration time 130 ms (open squares) and >130 ms (solid circles). *p < 0.01 within group versus baseline; p < 0.001 interaction time per group. Data are mean ± SE.

View larger version (21K): [in a new window]   Figure 2 Changes in end-diastolic volume index (EDVi) (A), end-systolic volume index (ESVi) (B), ejection fraction (EF) (C), and extent of wall motion abnormalities (%WMA) (D) during the follow-up in patients of the restrictive group with pre-discharge persistent short (130 ms) deceleration time (DT) (open squares) and reversible short (>130 ms) DT (solid circles). *p < 0.01 within group versus baseline; p < 0.001 interaction time per group. Data are mean ± SE.

View larger version (21K): [in a new window]   Figure 3 Cumulative survival rates for all-cause mortality according to baseline deceleration time (DT) (top) and pre-discharge DT (bottom).