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Angiotensin II receptors from peritransplantation through first-year post-transplantation and the risk of transplant coronary artery disease

Mohammed Yousufuddin, MD, MRCPE, MRCPI^*, Daniel J. Cook, PhD, Randall C. Starling, MD, MPH^*, Ashraf Abdo, MD, Philip Paul, MD, E. Murat Tuzcu, MD^*, Norman B. Ratliff, MD, Patrick M. McCarthy, MD, James B. Young, MD^* and Mohamad H. Yamani, MD^*,*

^* Department of Cardiovascular Medicine, USA
Allogen Laboratory, Cleveland, Ohio, USA
Department of Pathology, Cleveland, Ohio, USA
Cardiothoracic Surgery, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, Ohio, USA

View larger version (108K): [in a new window]   Figure 1 Intravascular ultrasound images of transplant coronary artery disease. (A) Transplant coronary artery at baseline showing an intimal thickness of 0.1 mm. (B) Transplant coronary artery at one year showing an intimal thickness of 0.8 mm.

View larger version (33K): [in a new window]   Figure 2 Regression plots showing relationship between serial angiotensin II type 1 receptor (AT1R) messenger ribonucleic acid and intravascular ultrasound indices of transplant coronary artery disease. CMIT = changes in maximal intimal thickness.

View larger version (56K): [in a new window]   Figure 3 Immunofluorescence labeling for angiotensin II type 1 receptor and von Willebrand factor on sections of the endomyocardial biopsies of the transplanted heart. (a) Biopsy section showing immunoreactivity for angiotensin II type 1 receptor predominantly in vascular and perivascular interstitial tissue. (b) Biopsy section demonstrating immunoreactivity for von Willebrand factor in the endothelium. (c) Biopsy section showing colocalization of angiotensin II type 1 receptor and von Willebrand factor in vascular endothelium.