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Metabolic syndrome amplifies the age-associated increases in vascular thickness and stiffness

Angelo Scuteri, MD, PhD^*,*, Samer S. Najjar, MD^*, Denis C. Muller, MS^*, Reubin Andres, MD^*, Hidetaka Hougaku, MD^*, E. Jeffrey Metter, MD^* and Edward G. Lakatta, MD^*

^* Laboratory of Cardiovascular Science, Laboratory of Clinical Investigation, Gerontology Research Center, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
U.O. Geriatria, INRCA, Rome, Italy

View larger version (23K): [in a new window]   Figure 1 Common carotid intima-media thickness (IMT) (A) and stiffness (B) by age quartile and metabolic syndrome (MS) status. p < 0.0001 for age effect; p < 0.01 for MS effect; and p = NS for interaction. Open bars = controls; solid bars = MS patients.

View larger version (24K): [in a new window]   Figure 2 Ratio of the prevalence of outliers for carotid intima-media thickness (IMT) and/or stiffness between metabolic syndrome patients (solid bars) and controls (open bars). Outliers for IMT or stiffness are defined as subjects having values for IMT or stiffness that exceed the 75th percentile levels in the study population. p < 0.001 across high quartile status by analysis of variance.