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Hematocrit and left ventricular mass: the Framingham Heart study

Manish G. Amin, MD^*, Hocine Tighiouart, MS^*, Daniel E. Weiner, MD, Paul C. Stark, PhD^*, John L. Griffith, PhD^*, Bonnie MacLeod, BS^*, Deeb N. Salem, MD and Mark J. Sarnak, MD^,*

^* Division of Clinical Care Research, Department of Medicine, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
Division of Nephrology, Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
Division of Cardiology, Department of Medicine, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts., USA

View larger version (10K): [in a new window]   Figure 1 (A) Relationship between hematocrit and left ventricular mass (LVM) index in men. (B) Relationship between hematocrit and LVM index in postmenopausal women. (C) Relationship between hematocrit and LVM index in premenopausal women. Hematocrit is treated as a continuous variable; LVM index is LVM normalized for height (g/m). All relationships shown are fully adjusted restricted cubic spline estimates for the relationship between hematocrit and LVM index. Other covariates in the multivariable model include: age, systolic blood pressure, body mass index, smoking status, and study cohort (original vs. offspring). Dashed lines = 95% confidence intervals.

View larger version (32K): [in a new window]   Figure 2 All values shown are fully adjusted mean left ventricular mass (LVM) indices. Covariates in multivariable model include: age, systolic blood pressure, body mass index, smoking status, and study cohort (original vs. offspring). Left ventricular mass index is LVM normalized for height (g/m). Hematocrit quartiles are the following (%): 44.5, 46.5, 48.3 in men, 40.8, 43.0, 45.0 in postmenopausal women, and 39.3, 41.1, 43.0 in premenopausal women. Mean (median) hematocrit values by quartile are the following (%): 42.9 (43.3), 45.5 (45.6), 47.3 (47.3), 50.2 (49.9) in men, 39.0 (39.4), 41.9 (42.0), 43.7 (43.7), 46.6 (46.0) in postmenopausal women, and 37.4 (37.9), 40.3 (40.3), 42.1 (42.0), 44.6 (44.4) in premenopausal women. Open bars = men; closed bars = postmenopausal women; striped bars = premenopausal women.

View larger version (16K): [in a new window]   Figure 3 Values shown are fully adjusted odds ratios (OR) with corresponding 95% confidence intervals comparing lowest quartile to rest of study sample in men and postmenopausal women, and to middle 50% of study sample in premenopausal women. Covariates in multivariable model include age, systolic blood pressure, body mass index, smoking status, and study cohort (original vs. offspring). LVH = left ventricular hypertrophy.