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Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease

Koji Ohashi, MD^*, Noriyuki Ouchi, MD, PhD^*, Shinji Kihara, MD, PhD^*,*, Tohru Funahashi, MD, PhD^*, Tadashi Nakamura, MD, PhD^*, Satoru Sumitsuji, MD, Toshiharu Kawamoto, MD, PhD, Satoru Matsumoto, MD^||, Hiroyuki Nagaretani, MD^*, Masahiro Kumada, MD^*, Yoshihisa Okamoto, MD^*, Hitoshi Nishizawa, MD, PhD^*, Ken Kishida, MD, PhD^*, Norikazu Maeda, MD^*, Hisatoyo Hiraoka, MD, PhD^*, Yoshio Iwashima, MD, Kazuhiko Ishikawa, MD, PhD, Mitsuru Ohishi, MD, PhD, Tomohiro Katsuya, MD, PhD, Hiromi Rakugi, MD, PhD, Toshio Ogihara, MD, PhD and Yuji Matsuzawa, MD, PhD^*

^* Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
Department of Geriatric Medicine, Graduate School of Medicine, Osaka University, Izumisano, Japan
Department of Cardiology, Rinku General Medical Center, Rinku, Japan
Department of Cardiology, National Hospital Kure Medical Center, Kure, Japan
^|| Department of Cardiology, Toyonaka Municipal Hospital, Toyonaka, Japan

View larger version (15K): [in a new window]   Figure 1 Association of I164T mutation, SNP94, and SNP276 with plasma adiponectin concentrations. (A) Plasma adiponectin levels in the subjects with wild type (WT) or I164T mutation in adiponectin gene. (B) Relationship between SNP94 genotypes and plasma adiponectin levels. (C) Relationship between SNP276 genotypes and plasma adiponectin levels. Columns and vertical bars denote mean and SE of the indicated sample numbers. *p < 0.05 vs. WT.