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The effects of nonselective non-aspirin non-steroidal anti-inflammatory medications on the risk of nonfatal myocardial infarction and their interaction with aspirin

Stephen E. Kimmel, MD, MS, FACC^*,*, Jesse A. Berlin, ScD^*, Muredach Reilly, MB^*, Jane Jaskowiak, BSN, RN^*, Lori Kishel, MS^*, Jesse Chittams, MS^* and Brian L. Strom, MD, MPH^*

^* Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Cardiovascular Division, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA

View larger version (16K): [in a new window]   Figure 1 Odds ratios (boxes) and 95% confidence intervals (bars) for odds of myocardial infarction among aspirin users versus nonusers of aspirin, stratified by non-aspirin non-steroidal anti-inflammatory drugs NANSAIDs). The p value is for test for interaction between aspirin and any NANSAID use. Odds ratios are adjusted for age; gender; race; cigarette smoking; insurance; number of doctor visits in the prior year; family history of coronary disease; body mass index; activity score; years of education; use of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors; and history of diabetes mellitus, hypertension, and hypercholesterolemia.

View larger version (10K): [in a new window]   Figure 2 Odds ratios (boxes) and 95% confidence intervals (bars) for odds of myocardial infarction among aspirin users versus nonusers of aspirin, stratified by frequency of non-aspirin non-steroidal anti-inflammatory drugs (NANSAIDs) and adjusted for same variables as in Figure 1. The p value is for interaction between aspirin and frequency of use of NANSAIDs. Numbers are less than total because of missing information on NANSAID frequency in 19 participants.