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J Am Coll Cardiol, 2004; 43:985-990, doi:10.1016/j.jacc.2003.08.064
© 2004 by the American College of Cardiology Foundation
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The effects of nonselective non-aspirin non-steroidal anti-inflammatory medications on the risk of nonfatal myocardial infarction and their interaction with aspirin

Stephen E. Kimmel, MD, MS, FACC*{dagger},*, Jesse A. Berlin, ScD*, Muredach Reilly, MB*{dagger}, Jane Jaskowiak, BSN, RN*, Lori Kishel, MS*, Jesse Chittams, MS* and Brian L. Strom, MD, MPH*

* Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
{dagger} Cardiovascular Division, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA



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Figure 1 Odds ratios (boxes) and 95% confidence intervals (bars) for odds of myocardial infarction among aspirin users versus nonusers of aspirin, stratified by non-aspirin non-steroidal anti-inflammatory drugs NANSAIDs). The p value is for test for interaction between aspirin and any NANSAID use. Odds ratios are adjusted for age; gender; race; cigarette smoking; insurance; number of doctor visits in the prior year; family history of coronary disease; body mass index; activity score; years of education; use of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors; and history of diabetes mellitus, hypertension, and hypercholesterolemia.

 


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Figure 2 Odds ratios (boxes) and 95% confidence intervals (bars) for odds of myocardial infarction among aspirin users versus nonusers of aspirin, stratified by frequency of non-aspirin non-steroidal anti-inflammatory drugs (NANSAIDs) and adjusted for same variables as in Figure 1. The p value is for interaction between aspirin and frequency of use of NANSAIDs. Numbers are less than total because of missing information on NANSAID frequency in 19 participants.

 




 
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