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J Am Coll Cardiol, 2004; 43:979-984, doi:10.1016/j.jacc.2003.08.062
© 2004 by the American College of Cardiology Foundation
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Inhibition of platelet aggregation by aspirin progressively decreases in long-term treated patients

Fabio M. Pulcinelli, PhD, MD*,*, Pasquale Pignatelli, PhD, MD*, Andrea Celestini, MD*, Silvia Riondino, PhD, MD*, Pier Paolo Gazzaniga, MD* and Francesco Violi, MD*

* Department of Experimental Medicine and Pathology, University "La Sapienza," Rome, Italy



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  		Figure 1 Box plot of the lag phase of platelet aggregation induced by collagen (2 µg/ml) before and after 2, 6, 12, and 24 months of aspirin treatment. NS = not significant.

 


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  		Figure 2 Box plot of the maximal percentage (Mx%) of platelet aggregation induced by collagen (2 µg/ml) before and after 2, 6, 12, and 24 months of aspirin treatment. NS = not significant.

 


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  		Figure 3 Box plot of the maximal percentage (Mx%) of platelet aggregation induced by adenosine diphosphate (ADP) (2 µmol/l) before and after 2, 6, 12, and 24 months of aspirin treatment. NS = not significant.

 


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  		Figure 4 Platelet aggregation (mean ± SEM) analyzed as lag phase and maximal percentage (Mx%) of aggregation in response to collagen (2 µg/ml) and as Mx% in response to adenosine diphosphate (ADP) (2 µmol/l) at baseline and throughout follow-up in patients given 100 mg/day or 300 to 330 mg/day aspirin.

 


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  		Figure 5 Platelet aggregation (mean ± SEM) analyzed as lag phase and maximum percentage of aggregation (Mx%) in response to collagen (2 µg/ml) and as Mx% in response to adenosine diphosphate (ADP) (2 µmol/l) at baseline and throughout follow-up in hypertensive and hypercholesterolemic patients.

 




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Copyright © 2004 by the American College of Cardiology Foundation.