This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Schillinger, M. Articles by Wagner, O. Search for Related Content PubMed PubMed Citation Articles by Schillinger, M. Articles by Wagner, O.

Heme oxygenase-1 genotype and restenosis after balloon angioplasty: a novel vascular protective factor

Martin Schillinger, MD^*, Markus Exner, MD, Erich Minar, MD^*, Wolfgang Mlekusch, MD^*, Marcus Müllner, MD, MSc(Epi), Christine Mannhalter, PhD, Fritz H. Bach, MD and Oswald Wagner, MD^,*

^* Angiology, University of Vienna, Medical Faculty, Vienna, Austria
Laboratory Medicine, University of Vienna, Medical Faculty, Vienna, Austria
Emergency Medicine, University of Vienna, Medical Faculty, Vienna, Austria
Harvard Medical School, Boston, Massachusetts, USA

View larger version (15K): [in a new window]   Figure 1 Course of C-reactive protein (median and 95% confidence interval of the median) from baseline to 48 h postintervention after femoropopliteal balloon angioplasty (n = 210) and after lower limb angiography (n = 103). Carriers and non-carriers of the class S allele in the heme oxygenase-1 (HO-1) gene promoter were compared. PTA = percutaneous transluminal angioplasty. Diamonds = carriers of the class S allele; squares = non-carriers of the class S allele.

View larger version (20K): [in a new window]   Figure 2 Frequency distribution of the guanosine thymidine (GT)n repeats in patients with and without restenosis after femoropopliteal balloon angioplasty (n = 210): lower number of (GT)n repeats in patients without restenosis compared with patients with restenosis (p = 0.001).

View larger version (23K): [in a new window]   Figure 3 Lower restenosis rates after femoropopliteal balloon angioplasty in homozygous and heterozygous class S allele carriers compared with non-carriers of the class S allele in the heme oxygenase-1 gene promoter (p < 0.001). Bars indicate percentage of patients with and without restenosis according to the heme oxygenase-1 (HO-1) promoter genotype; point estimates and 95% confidence interval indicate the percentage of patients with restenosis for each HO-1 promoter genotype.