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The Canadian study of the sirolimus-eluting stent in the treatment of patients with long de novo lesions in small native coronary arteries (C-SIRIUS)

Erick Schampaert, MD^*,*, Eric A. Cohen, MD, Michael Schlüter, PhD, François Reeves, MD, Mouhieddin Traboulsi, MD^||, Lawrence M. Title, MD^¶, Richard E. Kuntz, MD, MSc, FACC^#, Jeffrey J. Popma, MD, FACC^# the C-SIRIUS Investigators

^* Hôpital du Sacré-Coeur de Montréal, Montreal, Canada
Sunnybrook and Women's College Health Sciences Centre, Toronto, Canada
Center for Cardiology and Vascular Intervention, Hamburg, Germany
Centre Hospitalier de l'Université de Montréal, Pavillon Notre-Dame, Montreal, Canada
^|| Calgary Heart Centre, Calgary, Canada
^¶ Queen Elizabeth II Health Science Centre, Halifax, Nova Scotia, Canada
^# Brigham and Women's Hospital, Boston, Massachusetts, USA

View larger version (12K): [in a new window]   Figure 1 Late luminal loss by quantitative coronary angiography. Proximal edge: the 5-mm proximal to the stent. Distal edge: the 5-mm distal to the stent. Late loss was defined as the difference between the in-stent minimal lumen diameter at follow-up and the post-procedure in-stent minimal lumen diameter.

View larger version (13K): [in a new window]   Figure 2 Survival free from major adverse cardiac events (MACE). Absolute risk reduction: 14.3%, p = 0.029.