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The cholesteryl ester transfer protein (CETP) TaqIB polymorphism in the cholesterol and recurrent events study: no interaction with the response to pravastatin therapy and no effects on cardiovascular outcome

A prospective analysis of the CETP TaqIB polymorphism on cardiovascular outcome and interaction with cholesterol-lowering therapy

Greetje J. de Grooth, MD, PhD^*, Kim E. Zerba, PhD, Shu-Pang Huang, PhD, Zenta Tsuchihashi, PhD, Todd Kirchgessner, PhD, René Belder, MD, Priya Vishnupad, BSc, Beihong Hu, MSc, Anke H. E. M. Klerkx, PhD^*, Aeilko H. Zwinderman, PhD, J. Wouter Jukema, MD, PhD, Frank M. Sacks, MD, PhD^||, John J. P. Kastelein, MD, PhD^*,* and Jan Albert Kuivenhoven, PhD^*

^* Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Bristol-Myers Squibb Co, Princeton, New Jersey, USA
Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
^|| Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA

View larger version (13K): [in a new window]   Figure 1 Gender-TaqIB genotype-specific odds ratios for death from cardiovascular disease or nonfatal myocardial infarction in the pravastatin relative to placebo group after five years of treatment. The bars represent the upper limit of the 95% confidence interval of the odds ratio.