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Molecular normalization of dystrophin in the failing left and right ventricle of patients treated with either pulsatile or continuous flow-type ventricular assist devices

Matteo Vatta, PhD^*, Sonny J. Stetson, BSc^||¶, Shinawe Jimenez, MD^*, Mark L. Entman, MD^¶#, George P. Noon, MD^¶#, Neil E. Bowles, PhD^*, Jeffrey A. Towbin, MD^* and Guillermo Torre-Amione, MD, PhD^||¶,*

^* Department of Pediatrics (Cardiology), Baylor College of Medicine, Houston, Texas, USA
Department of Reproductive and Developmental Sciences, University of Trieste, Trieste, Italy
Section of Cardiology, Houston, Texas, USA
Cardiovascular Science, Houston, Texas, USA
^|| Molecular and Human Genetics), Houston, Texas, USA
^¶ The Winters Center for Heart Failure Research, Houston, Texas, USA
^# The Gene and Judy Campbell Laboratory for Cardiac Transplant Research, and the Methodist DeBakey Heart Center, Baylor College of Medicine, Houston, Texas, USA

View larger version (58K): [in a new window]   Figure 1 Dystrophin expression of normal and failing left ventricular (LV) and right ventricular (RV) samples. Selected immunohistochemistry for the detection of the amino (N)-terminus of dystrophin in normal control (LV and RV) and failing (LV and RV) myocardial samples (A). Staining scores for the immunohistochemical detection of N-terminus (B) and C-terminus (C) dystrophin in samples from normal controls and failing hearts.

View larger version (104K): [in a new window]   Figure 2 Effect of mechanical support with either a pulsatile or continuous-type left ventricular assist device on failing left ventricular (LV) and right ventricular (RV) samples. Immunohistochemical detection of N-terminus dystrophin in LV and RV myocardial samples from patients treated with continuous flow devices, pulsatile flow devices, and normal controls (A). Immunohistochemical detection of C-terminus dystrophin in LV and RV myocardial samples from patients treated with continuous flow devices, pulsatile flow devices, and normal controls (B). Staining scores for the immunohistochemical detection of N-terminus (C) and C-terminus (D) dystrophin in LV and RV samples from controls, failing hearts, and myocardial samples from patients treated with either continuous or pulsatile flow devices.