This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Leuchte, H. H. Articles by Behr, J. Search for Related Content PubMed PubMed Citation Articles by Leuchte, H. H. Articles by Behr, J.

Clinical significance of brain natriuretic peptide in primary pulmonary hypertension

Hanno H. Leuchte, MD^*,*, Michael Holzapfel^*, Rainer A. Baumgartner^*, Isabelle Ding, MD^*, Claus Neurohr, MD^*, Michael Vogeser, MD, Tilman Kolbe, MD^*, Martin Schwaiblmair, MD^* and Jürgen Behr, MD^*

^* Division of Pulmonary Diseases, Department of Internal Medicine I, Munich, Germany
Department of Clinical Chemistry, Ludwig Maximilians University, Klinikum Grosshadern, Munich, Germany

View larger version (21K): [in a new window]   Figure 1 (A to D) Correlation of resting hemodynamic parameters with brain natriuretic peptide (BNP) levels in primary pulmonary hypertension (PPH). (A) Pulmonary vascular resistance (PVR) vs. BNP; r = 0.61; p = 0.001; (B) mean pulmonary artery pressure (PAP) vs. BNP; r = 0.49; p = 0.01; (C) right atrial pressure (RAP) vs. BNP; r = 0.78; p < 0.001; (D) cardiac index (CI) vs. BNP; r = –0.48; p < 0.05.

View larger version (9K): [in a new window]   Figure 2 (A to C) Correlation of exercise parameters with brain natriuretic peptide (BNP) levels in primary pulmonary hypertension. (A) BNP vs. 6-min walk; r = –0.7; p < 0.001; (B) BNP vs. peak oxygen uptake (peak VO2); r = –0.61; p < 0.01; (C) BNP vs. World Health Organization (WHO) functional class, r = 0.79; p < 0.001. WHO class II vs. class III; p < 0.001.

View larger version (10K): [in a new window]   Figure 3 (A, B) Correlation of World Health Organization (WHO) functional class with peak oxygen uptake (peak VO2) and 6-min walk (6 MW) in primary pulmonary hypertension. (A) Correlation of WHO functional class with peak VO2; r = –0.73; p < 0.001; (B) correlation of WHO functional class with 6 MW; r = –0.86; p < 0.001.