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Technetium^99m sestamibi myocardial perfusion imaging predicts clinical outcome in the community outpatient setting

The Nuclear Utility in the Community (NUC) Study

Gregory S. Thomas, MD, MPH, FACC^*,*, Michael I. Miyamoto, MD, MS, FACC^*, A. Peter Morello, III, ScB^*, Haresh Majmundar, CNMT^*, Jennifer J. Thomas, BA^*, Christine H. Sampson^*, Rory Hachamovitch, MD, MSc, FACC and Leslee J. Shaw, PhD

^* Mission Internal Medical Group, Mission Viejo, California, USA
Cardiovascular Division, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Atlanta Cardiovascular Research Institute, Atlanta, Georgia, USA

View larger version (93K): [in a new window]   Figure 1 Representative examples of dual isotope imaging with mild (A), moderate (B), and severe (C) transient ischemic dilation scoring.

View larger version (16K): [in a new window]   Figure 2 Cumulative two-year event-free survival stratified by defect extent and severity score (A) and reversibility score (B), p < 0.001 for each.

View larger version (32K): [in a new window]   Figure 3 Cumulative two-year event-free survival stratified by transient ischemic dilation for all patients (A), only those undergoing dual isotope imaging (B), and those undergoing exercise (C) or adenosine (D) stress, p < 0.0001 for each.

View larger version (22K): [in a new window]   Figure 4 (A) Cumulative two-year event-free survival based on post-stress ejection fraction (EF), p < 0.001. Dotted lines represent 95% confidence intervals. Cumulative two-year event-free survival stratified by reversibility score in patients with EFs 40 (B) and <40% (C), p < 0.001 for each.