Impaired brachial artery endothelium-dependent and -independent vasodilation in men with erectile dysfunction and no other clinical cardiovascular disease
Daniel R. Kaiser, PhD*,
Kevin Billups, MD ,
Carol Mason, NP*,
Rebecca Wetterling, BS*,
Jennifer L. Lundberg, MS* and
Alan J. Bank, MD, FACC*,*
* St. Paul Heart Clinic, St. Paul, USA
EpiCenter for Sexual Health and Medicine, St. Paul, Minnesota, USA
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Figure 1 Brachial artery flow-mediated vasodilation (FMV) was significantly reduced in erectile dysfunction patients (circles) versus normal control subjects (squares) over the whole time period (p = 0.014). The difference was also significant when comparing the percent dilation from baseline to 60 s after cuff release (p = 0.05). * denotes a significant increase compared to erectile dysfunction over the entire curve.
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Figure 2 The vasodilator response to 0.4 mg sublingual nitroglycerin (NTG) was significantly impaired in erectile dysfunction (ED) patients versus normal control subjects (13.0 ± 1.4% vs. 17.8 ± 1.4%, p = 0.02). * denotes a significant decrease compared to normal.
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Figure 3 There was a significant correlation between endothelium-dependent (flow-mediated vasodilation) and -independent (nitroglycerin [NTG]) vasodilation in erectile dysfunction patients (circles) (r = 0.59, p < 0.05) but not in normal control subjects (squares) (r = 0.05, p = NS).
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