Adverse outcome in aortic sclerosis is associated with coronary artery disease and inflammation
Harish R. Chandra, MD, MPH*,
James A. Goldstein, MD*,
Nivedita Choudhary, MD, MPH*,
Carol S. O'Neill, RN, BSN*,
Peter B. George, MD*,
Sreenivasulu R. Gangasani, MD*,
Lynn Cronin, MD*,
Pamela A. Marcovitz, MD*,
Andrew M. Hauser, MD* and
William W. O'Neill, MD*,*
* Division of Cardiology, Department of Internal Medicine, William Beaumont Hospital, Royal Oak, Michigan, USA
View larger version (21K):
[in a new window]
|
Figure 1 Kaplan-Meier analysis of event-free survival in patients according to the severity of aortic sclerosis. Event-free survival = freedom from cardiac death and nonfatal myocardial infarction.
|
|
View larger version (16K):
[in a new window]
|
Figure 2 Incidence of cardiac death and nonfatal myocardial infarction (MI) at one year by severity of aortic (A.) sclerosis and C-reactive protein (CRP) tertiles. Tertiles: <0.32; 0.32 to 1.18; >1.18 (mg/dl); levels available on 395 of 415 patients.
|
|
View larger version (18K):
[in a new window]
|
Figure 3 Kaplan-Meier analysis of event-free survival in patients with aortic sclerosis with respect to C-reactive protein (CRP) levels. Event-free survival = freedom from cardiac death and nonfatal myocardial infarction. Tertiles: <0.32; 0.32 to 1.18; >1.18 (mg/dl); levels available on 190 of 203 patients with aortic sclerosis.
|
|
View larger version (17K):
[in a new window]
|
Figure 4 Cumulative incidence of cardiac death and nonfatal myocardial infarction either at index admission or at one year in patients with and without known coronary artery disease (CAD) in relation to their aortic valves (normal or any sclerosis by echocardiography) and systemic inflammation (low C-reactive protein [CRP] = 1st tertile, <0.32 vs. high CRP = 2nd and 3rd tertiles,  0.32 mg/dl); levels available on 395 of 415 patients; A.Scl = aortic sclerosis, + = present, – = absent.
|
|
View larger version (20K):
[in a new window]
|
Figure 5 Cox multivariate analysis: one-year outcome of cardiac death and nonfatal myocardial infarction (MI). C.I. = confidence interval; CRP = C-reactive protein. Tertiles <0.32; 0.32 to 1.18; >1.18 (mg/dl).
|
|
|
