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Eptifibatide provides additional platelet inhibition in Non–ST-Elevation myocardial infarction patients already treated with aspirin and clopidogrel

Results of the platelet activity extinction in Non–Q-Wave myocardial infarction with aspirin, clopidogrel, and eptifibatide (PEACE) study

Miles Dalby, MD^*, Gilles Montalescot, MD, PhD^*,*, Claire Bal dit Sollier, MD, Eric Vicaut, MD, PhD, Thierry Soulat, MD, Jean-Philippe Collet, MD, PhD^*, Rémi Choussat, MD^*, Vanessa Gallois, MSc^*, Gérard Drobinski, MD, PhD^*, Ludovic Drouet, MD and Daniel Thomas, MD^*

^* Institut de Cardiologie, Pitié-Salpétrière University Hospital, Paris, France
Department of Haematology, Hospital Lariboisiere, Paris, France
Unite de Recherche Clinique, Hospital Lariboisiere, Paris, France

View larger version (37K): [in a new window]   Figure 1 Charts of conformationally active glycoprotein IIb/IIIa receptor expression (PAC-1) and anti-fibrinogen (Fg) before clopidogrel administration (T1), >2 h after clopidogrel (T2), and during eptifibatide infusion (T3). Receptor expression and Fg binding are expressed on the y axis as the mean number of sites expressed per platelet. ADP = adenosine diphosphate.

View larger version (48K): [in a new window]   Figure 2 Charts of total glycoprotein IIb/IIIa receptor expression (P2) and P-selectin expression before clopidogrel administration (T1), >2 h after clopidogrel (T2), and during eptifibatide infusion (T3). Receptor expression and fibrinogen binding are expressed on the y axis as the mean number of sites expressed per platelet. "ns" is indicated in parenthesis for p values <0.05 but >0.0036 and therefore are not significant after Bonferonni correction. ADP = adenosine diphosphate.

View larger version (35K): [in a new window]   Figure 3 Charts of platelet microparticle count as a function of blood volume (MPV) (top panel) and platelet count (MPP) (bottom panel) on the y axis before clopidogrel administration (T1), >2 h after clopidogrel (T2), and during eptifibatide infusion (T3).