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Prognostic value of remnant-like lipoprotein particle levels in patients with coronary artery disease and type ii diabetes mellitus

Hironobu Fukushima, MD^*, Seigo Sugiyama, MD, PhD^*, Osamu Honda, MD^*, Shunichi Koide, MD^*, Shinichi Nakamura, MD^*, Tomohiro Sakamoto, MD, PhD^*, Michihiro Yoshimura, MD, PhD^*, Hisao Ogawa, MD, PhD^*, Daisuke Fujioka, MD and Kiyotaka Kugiyama, MD, PhD^,*

Department of Internal Medicine II, Yamanashi University, Faculty of Medicine, Yamanashi, Japan
^* Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan

View larger version (12K): [in a new window]   Figure 1 Kaplan-Meier curves comparing the probability of future coronary events in 120 patients with type II diabetes mellitus and coronary artery disease, according to remnant-like lipoprotein particles (RLP) cholesterol levels during a maximum follow-up period of 24 months after enrollment. The end points were either re-admission or coronary revascularization (percutaneous coronary intervention or coronary artery bypass graft surgery) due to recurrent and refractory angina pectoris, nonfatal myocardial infarction, or cardiac death. The time to the first coronary event was recorded. The cut-off level of RLP cholesterol (4.7 mg/dl) was set at the 75th percentile of the distribution of RLP cholesterol levels in age- and gender-matched control subjects. Fifty-two patients had levels of RLP cholesterol >4.7 mg/dl, whereas 68 patients had levels 4.7 mg/dl.