Comparative effects of valsartan versus amlodipine on left ventricular mass and reactive oxygen species formation by monocytes in hypertensive patients with left ventricular hypertrophy
Kenichi Yasunari, MD, PhD*,*,
Kensaku Maeda, MD*,
Takanori Watanabe, MD*,
Munehiro Nakamura, MD*,
Junichi Yoshikawa, MD, PhD, FACC* and
Akira Asada, MD, PhD*
* Department of General Medicine and Cardiology, Graduate School of Medicine, Osaka City University, Osaka, Japan
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Figure 1 Relationships between reactive oxygen species (ROS) formation by monocytes (MNCs) and left ventricular mass index (LVMI) and between C-reactive protein (CRP) and LVMI (n = 104).
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Figure 2 Effect of valsartan (n = 50) and amlodipine (n = 50) on left ventricular mass index (LVMI). The open circles on the vertical bars represent the mean value ± SD. p < 0.01 for baseline versus six months later in the valsartan group; p < 0.01 for baseline versus six months later in the amlodipine group.
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Figure 3 Effect of valsartan (n = 50) and amlodipine (n = 50) on reactive oxygen species (ROS) formation by monocytes (MNCs). The open circles on the vertical bars represent the mean ± SD. p < 0.01 for baseline versus six months later in the valsartan group; p = 0.1 for baseline versus six months later in the amlodipine group.
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Figure 4 Relationships between the decrease ( ) in reactive oxygen species (ROS) formation by monocytes (MNCs) and the decrease in left ventricular mass index (LVMI) and between the decrease in C-reactive protein (CRP) and the decrease in LVMI in the valsartan-treated group (n = 50).
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Figure 5 Effect of valsartan (n = 50) and amlodipine (n = 50) on C-reactive protein levels. The open circles on the vertical bars represent the mean value ± SD. p < 0.01 for baseline versus six months later in the valsartan group; p = 0.7 for baseline versus six months later in the amlodipine group.
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