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Effects of loop diuretics on myocardial fibrosis and collagen type I turnover in chronic heart failure

Begoña López, PhD^*, Ramón Querejeta, MD, PhD, Arantxa González, PhD^*, Eloy Sánchez, MD, Mariano Larman, MD and Javier Díez, MD, PhD^*,*

^* Area of Cardiovascular Pathophysiology, Centre for Applied Medical Research, Pamplona, Spain
Department of Cardiology and Cardiovascular Surgery, University Clinic, School of Medicine, University of Navarra, Pamplona, Spain
Division of Cardiology, General Hospital, San Sebastián, Spain
Division of Hemodynamics, Guipuzcoa Policlinics, Donostia University Hospital, San Sebastián, Spain

View larger version (18K): [in a new window]   Figure 1 Effects of furosemide (n = 17) and torasemide (n = 19) on collagen volume fraction (CVF) in patients with chronic heart failure. NS = nonsignificant.

View larger version (131K): [in a new window]   Figure 2 Histologic sections of a myocardial biopsy specimen from a patient with chronic heart failure before (upper left panel) and after (upper right panel) treatment with furosemide. Histologic sections of a myocardial biopsy specimen from a patient before (lower left panel) and after (lower right panel) treatment with torasemide. (Picrosirius red stain; magnification x20.) CVF = collagen volume fraction.

View larger version (17K): [in a new window]   Figure 3 Effects of furosemide (n = 17) and torasemide (n=19) on serum carboxy-terminal peptide of procollagen type I (PIP) in patients with chronic heart failure. NS = nonsignificant.

View larger version (14K): [in a new window]   Figure 4 Direct correlation (y = 68.08 + 9.41x) between collagen volume fraction (CVF) and serum carboxy-terminal peptide of procollagen type I (PIP) in patients with chronic heart failure before and after treatment.

View larger version (16K): [in a new window]   Figure 5 Effects of furosemide (n = 17) and torasemide (n = 19) on serum carboxy-terminal telopeptide of collage type I (CITP) in patients with chronic heart failure. NS = nonsignificant.