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Palliation of allograft vasculopathy with transluminal angioplasty

A decade of experience

Raymond L. Benza, MD^*,*, Gilbert J. Zoghbi, MD^*, Jose Tallaj, MD^*, Robert Brown, BS, James K. Kirklin, MD, Meloneysa Hubbard, RN^*, Barry Rayburn, MD^*, Brian Foley, MD^*, David C. McGiffin, MD, Laura J. Pinderski, MD, PhD^*, Vijay Misra, MD^* and Robert C. Bourge, MD^*

^* Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama, USA
Department of Medicine, Birmingham VA Medical Center, Birmingham, Alabama, USA
Department of Surgery, Division of Cardiovascular Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA

View larger version (22K): [in a new window]   Figure 1 Kaplan-Meier depiction of the event re-percutaneous coronary intervention (PCI) for the 219 angioplasties. The parametric hazard model is plotted as the smooth curve. Error bars and parametric confidence limits are 70%. The number of vessels still at risk of re-PCI is noted at the bottom of the plot.

View larger version (29K): [in a new window]   Figure 2 Kaplan-Meier depiction of the event restenosis for the 219 angioplasties (only 174 had follow-up angiograms). The parametric hazard model is plotted (survival and hazard) as the smooth curve. Error bars and parametric confidence limits are 70%. The number of vessels still at risk of restenosis is noted at the bottom of the plot. PCI = percutaneous coronary intervention.

View larger version (28K): [in a new window]   Figure 3 Kaplan-Meier depiction of the event restenosis for the 219 angioplasties (only 174 had follow-up angiograms) stratified by use of a stent. Error bars are 70%. The number still at risk at selected time points is indicated in parentheses. PCI = percutaneous coronary intervention.

View larger version (29K): [in a new window]   Figure 4 Kaplan-Meier depiction of the event restenosis for the 219 angioplasties (only 174 had follow-up angiograms) stratified by use of high-dose anti-proliferatives (AP). Error bars are 70%. The number still at risk at selected time points is indicated in parentheses. PCI = percutaneous coronary intervention.

View larger version (31K): [in a new window]   Figure 5 Kaplan-Meier depiction of the event restenosis for the 219 angioplasties (only 174 had follow-up angiograms) stratified by the era in which the percutaneous coronary intervention (PCI) was done. Error bars are 70%. The number still at risk at selected time points is indicated in parentheses.

View larger version (34K): [in a new window]   Figure 6 Parametric prediction from the three-phase hazard model with 70% confidence limits. The pre-percutaneous coronary intervention (PCI) stenosis is set at 70%, and the era is set at 1997 or later. The curves represent the predicted probability of restenosis for all combinations of the remaining risk factors use of stent (yes/no) and high-dose anti-proliferatives (AP) (yes/no).