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Urinary biopyrrins levels are elevated in relation to severity of heart failure

Jun Hokamaki, MD^*, Hiroaki Kawano, MD^*,*, Michihiro Yoshimura, MD^*, Hirofumi Soejima, MD^*, Shinzo Miyamoto, MD^*, Ichiro Kajiwara, MD^*, Sunao Kojima, MD^*, Tomohiro Sakamoto, MD^*, Seigo Sugiyama, MD^*, Nobutaka Hirai, MD^*, Hideki Shimomura, MD, Yasuhiro Nagayoshi, MD, Kenichi Tsujita, MD, Izuru Shioji, BS, Shinya Sasaki, BS and Hisao Ogawa, MD^*

^* Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
Division of Cardiology, Fukuoka Tokushukai Hospital, Fukuoka, Japan
Shino-Test Corporation, Tokyo, Japan

View larger version (24K): [in a new window]   Figure 1 Comparison of urinary levels of biopyrrins/creatinine among the patients in New York Heart Association (NYHA) functional classes I, II, and III/IV and controls. The horizontal line in the box represents the median value; the boxed area is the interquartile range; and the whiskers are the 10% to 90% range.

View larger version (19K): [in a new window]   Figure 2 Correlation between log biopyrrins/creatinine levels and log B-type natriuretic peptide (BNP) levels.

View larger version (15K): [in a new window]   Figure 3 (A) Bar graphs comparing New York Heart Association (NYHA) functional classes before and after the active treatment of heart failure (mean ± SEM). (B) Box plots of urinary biopyrrins/creatinine levels before and after the active treatment of heart failure. The horizontal line in the box represents the median value; the boxed area is the interquartile range; and the whiskers are the 10% to 90% range.