High lipoprotein(a) levels and small apolipoprotein(a) sizes are associated with endothelial dysfunction in a multiethnic cohort
Henry D. Wu, MD*,*,
Lars Berglund, MD PhD*,
Clarito Dimayuga, MD*,
Jeffery Jones, MS*,
Robert R. Sciacca, EngScD, MS*,
Marco R. Di Tullio, MD* and
Shunichi Homma, MD*
* Department of Medicine, Columbia University, New York, New York, USA
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Figure 1 Scatterplot of lipoprotein(a), or Lp(a), levels and flow-mediated dilation (FMD) showing a significant inverse correlation. Open diamonds = Caucasians; solid squares = African Americans; open triangles = Hispanics. r = –0.33; p < 0.005.
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Figure 2 Scatterplot of apolipoprotein(a), or apo(a), sizes and flow-mediated dilation (FMD). Open diamonds = Caucasians; solid squares = African Americans; open triangles = Hispanics.
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Figure 3 Endothelium-dependent flow-mediated dilation (FMD) according to four categories based on low and high lipoprotein(a), or Lp(a), levels (cutoff, 30 mg/dl) with small and large apolipoprotein(a), or apo(a), sizes (cutoff, 22 kringle 4 repeats). n indicates number of subjects in each category. *p < 0.001 between small and large apo(a) size groups.
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