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Impact of intravenous Beta-Blockade before primary angioplasty on survival in patients undergoing mechanical reperfusion therapy for acute myocardial infarction

Amir Halkin, MD^*, Cindy L. Grines, MD, FACC, David A. Cox, MD, FACC, Eulogio Garcia, MD, Roxana Mehran, MD, FACC^*, James E. Tcheng, MD, FACC^||, John J. Griffin, MD, FACC^¶, Giulio Guagliumi, MD^#, Bruce Brodie, MD, FACC^**, Mark Turco, MD, FACC, Barry D. Rutherford, MD, FACC, Eve Aymong, MD^*, Alexandra J. Lansky, MD, FACC^* and Gregg W. Stone, MD, FACC^*,*

^* Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, New York, New York, USA
William Beaumont Hospital, Royal Oak, Michigan, USA
Mid Carolina Cardiology, Charlotte, North Carolina, USA
Hospital Gregorio Maranon, Madrid, Spain
^|| Duke Clinical Research Institute, Durham, North Carolina, USA
^¶ Virginia Beach General Hospital, Virginia Beach, Virginia, USA
^# Ospedali Riuniti di Bergamo, Bergamo, Italy
^** Moses Cone Memorial Hospital, Greensboro, North Carolina, USA
Washington Adventist Hospital, Tacoma Park, Maryland, USA
St. Luke's Hospital, Kansas City, Missouri, USA

View larger version (11K): [in a new window]   Figure 1 Freedom from death among patients treated (BB+, solid line) or not treated (BB–, broken line) with pre-procedural intravenous beta-blockers before percutaneous coronary intervention. BB = beta-blocker.

View larger version (10K): [in a new window]   Figure 2 Hazard ratios for 30-day mortality in CADILLAC patients with respect to oral beta-blocker medication use before acute myocardial infarction, stratified by pre-percutaneous coronary intervention intravenous beta-blocker administration.

View larger version (24K): [in a new window]   Figure 3 Change in left ventricular ejection fraction (LVEF) from baseline to seven-month follow-up among patients with paired ventriculograms. BB+ (solid bars) and BB– (open bars) denote patients treated or untreated with pre-procedural beta-blockers, respectively. Solid bars = index LVEF. Open bars = follow-up LVEF.