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Mechanism(s) of selective systolic blood pressure reduction after a low-dose combination of perindopril/Indapamide in hypertensive subjects: comparison with atenolol

Gérard M. London, MD^*, Roland G. Asmar, MD, Michaël F. O'Rourke, MD, Michel E. Safar, MD^,* REASON Project Investigators

^* Hôpital Manhès, Fleury-Mèrogis, France
L'Institut Cardiovasculaire, Paris, France
St. Vincent Hospital, Darlinghurst, Australia
Hôtel-Dieu, Paris, France

View larger version (20K): [in a new window]   Figure 1 Overall intention-to-treat population: adjusted values (± SD) in brachial systolic blood pressure (SBP) and diastolic blood pressure (DBP), measured each month (M) in perindopril/indapamide (Per/Ind) and atenolol groups. There was no difference between groups for DBP but only for SBP and exclusively at M12.

View larger version (28K): [in a new window]   Figure 2 Population with central measurements: adjusted changes (± SD) in systolic blood pressure (SBP) (%). With perindopril/indapamide (Per/Ind) (lined bars), SBP reduction (%) was more pronounced than for atenolol (open bars) at both the carotid and the brachial artery sites between 0 to 6 months and 0 to 12 months. Between 6 to 12 months, the SBP reduction continued under Per/Ind and tended to decline under atenolol. The p values are represented as Per/Ind versus atenolol.