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Elevation of plasma brain natriuretic peptide is a hallmark of diastolic heart failure independent of ventricular hypertrophy

Hitoshi Yamaguchi, MD, PhD^*,, Junichi Yoshida, MD^,, Kazuhiro Yamamoto, MD, PhD, FACC^,*, Yasushi Sakata, MD, PhD, Toshiaki Mano, MD, PhD, Noriyuki Akehi, MD, Masatsugu Hori, MD, PhD, FACC, Young-Jae Lim, MD, PhD^*, Masayoshi Mishima, MD, PhD^* and Tohru Masuyama, MD, PhD, FACC

^* Department of Cardiology, Kawachi General Hospital, Higashi-Osaka, Japan
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan

View larger version (16K): [in a new window]   Figure 1 Comparison of the left ventricular (LV) mass index, plasma brain natriuretic peptide (BNP) level, and plasma atrial natriuretic peptide (ANP) level between the two groups. The vertical bars indicate the range of values. The middle horizontal bars indicate means, and the upper and lower horizontal bars indicate standard errors (SEM).

View larger version (21K): [in a new window]   Figure 2 Comparison of plasma norepinephrine level, plasma renin activity, and plasma aldosterone level between the two groups. The vertical bars indicate the range of values. The middle horizontal bars indicate means, and the upper and lower horizontal bars indicate standard errors (SEM). DHF = diastolic heart failure.