New upper limit of physiologic cardiac hypertrophy in Japanese participants in the 100-km ultramarathon
Junzo Nagashima, MD* ,*,
Haruki Musha, MD ,
Hideomi Takada, MD* and
Masahiro Murayama, MD*
* Internal Medicine Section, Yokohama Sports Medical Center, Yokohama, Japan
Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan
Division of Cardiology, St. Marianna University School of Medicine, Yokohama City Seibu Hospital, Yokohama, Japan

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Figure 1 A representative echocardiography recording. EF = ejection fraction; FS = fractional shortening; IVS = interventricular septal thickness; LV = left ventricular; LVD = left ventricular end-diastolic diameter; LVPW = left ventricular posterior wall thickness; RVD = right ventricular end-diastolic diameter.
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Figure 2 M-mode echocardiography in 100-km ultramarathon runners. (A) A 44-year-old man. The left ventricular end-diastolic diameter is 75 mm. (B) A 48-year-old man. The aortic diameter (Ao) is 50 mm. (C) A 37-year-old man. The left atrial diameter (LA) is 49 mm. LV = left ventricle; RVOT = right ventricular outflow tract.
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Figure 3 Correlation of heart rate (HR) and systolic wall stress (WS) with age, body surface area (BSA), and monthly running distance.
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Figure 4 Correlation of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with the age, body surface area (BSA), and monthly running distance.
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Figure 5 Correlation of left ventricular end-diastolic diameter (Dd) and left ventricular end-systolic diameter (Ds) with age, body surface area (BSA), and monthly running distance.
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Figure 6 Correlation of aortic diameter (Ao) and left atrial diameter (LA) with age, body surface area (BSA), and monthly running distance.
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Figure 7 Correlation of interventricular septal thickness (IVS) and posterior wall thickness (PW) with the age, body surface area (BSA), and monthly running distance.
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