Effects of intravenous dobutamineon coronary vasomotion in humans
Emanuele Barbato, MD*,
Jozef Bartunek, MD, PhD*,
Eric Wyffels, MD*,
William Wijns, MD, PhD*,
Guy R. Heyndrickx, MD, PhD* and
Bernard De Bruyne, MD, PhD*,*
* Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
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Figure 1 Study protocols. BL = baseline; DOB = dobutamine; IC = intracoronary; ISDN = isosorbide dinitrate; IV = intravenous; Phento = phentolamine; QCA = quantitative coronary angiography; REC = recovery period; SAL = saline.
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Figure 2 Effect of dobutamine (dob) and saline on the rate–pressure product (rpp). *p < 0.05 vs. baseline (bl) for dobutamine 20, 30, and 40 µg/kg per min in groups 1, 3, 4, and 6; for dobutamine 30 and 40 µg/kg per min in group 5; and for isdn in group 1.  p < 0.05 vs. preceding value in groups 1, 3, 4, 5, and 6. white boxes represent group 1 (normal coronary arteries); white circles = group 2 (normal coronary arteries, but dobutamine replaced by saline); blue diamonds = group 3 (mildly atherosclerotic coronary arteries); black triangles = group 4 (stenotic coronary arteries); white triangles = group 5 (stenotic coronary arteries, pretreated with phentolamine); blue triangles = group 6 (stenotic coronary arteries, pretreated with L-arginine).
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Figure 3 Effect of dobutamine on luminal diameter (LD) changes in group 1 (normal coronary arteries), group 3 (mildly atherosclerotic coronary arteries), and group 4 (stenotic coronary arteries). *p < 0.05 vs. group 1. For an explanation of symbols and abbreviations, see Figure 2.
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Figure 4 Effect of dobutamine on luminal diameter (LD) changes in group 4 (stenotic coronary arteries), group 5 (stenotic coronary arteries, pretreated with phentolamine), and group 6 (stenotic coronary arteries, pretreated with L-arginine). *p < 0.05 vs. group 4. p < 0.05 vs. group 6. For an explanation of symbols and abbreviations, see Figure 2.
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