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Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias

Steven L. Higgins, MD, FACC^*,*, John D. Hummel, MD, FACC, Imran K. Niazi, MD, FACC, Michael C. Giudici, MD, FACC, Seth J. Worley, MD, FACC^||, Leslie A. Saxon, MD, FACC^¶, John P. Boehmer, MD, FACC^#, Michael B. Higginbotham, MD^**, Teresa De Marco, MD, FACC^¶, Elyse Foster, MD, FACC^¶ and Patrick G. Yong, MSEE

^* Scripps Memorial Hospital, La Jolla, California, USA
Riverside Methodist Hospital, Columbus, Ohio, USA
St. Luke's Presbyterian Hospital, Milwaukee, Wisconsin, USA
Genesis Medical Center, Davenport, Iowa, USA
^|| Lancaster General Hospital, Lancaster, Pennsylvania, USA
^¶ University of California San Francisco Medical Center, San Francisco, California, USA
^# The Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA
^** Duke University School of Medicine, Durham, North Carolina, USA
Guidant Corporation, St. Paul, Minnesota, USA

View larger version (22K): [in a new window]   Figure 1 Study design for each phase. Phase I (top) was a crossover design (n = 248); Phase II (bottom) was a parallel design (n = 333). CRT = cardiac resynchronization therapy; Rand = randomization time.

View larger version (15K): [in a new window]   Figure 2 Kaplan-Meier curves for all-cause mortality (left) and all-cause mortality and heart failure (HF) hospitalization (right). CRT = cardiac resynchronization therapy.