Predictors of late development of heart failure in stable survivors of myocardial infarction
The CARE study
Eldrin F. Lewis, MD, MPH*,
Lemuel A. Moye, MD, PhD ,
Jean L. Rouleau, MD, FACC ,
Frank M. Sacks, MD*,
J. Malcolm O. Arnold, MD, FACC ,
J. Wayne Warnica, MD, FACC||,
Greg C. Flaker, MD, FACC¶,
Eugene Braunwald, MD, FACC* and
Marc A. Pfeffer, MD, PhD, FACC*,*
* Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
University of Texas School of Public Health, Houston, Texas, USA
University of Toronto, Toronto, Ontario, Canada
London Health Sciences Center, London, Ontario, Canada
|| Foothills Hospital, Calgary, Alberta, Canada
¶ University of Missouri Hospital and Clinics, Columbia, Missouri, USA

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Figure 1 Cumulative incidence of hospitalization for heart failure (HF) and death or hospitalization for HF in patients enrolled in the CARE trial without a previous history of HF. The upper line represents the cumulative incidence of all-cause mortality or hospitalization for HF, and the lower line represents only HF hospitalizations.
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Figure 2 The impact of age on the development of heart failure after an myocardial infarction in the CARE trial.
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Figure 3 The impact of baseline left ventricular ejection fraction (LVEF) on the development of heart failure after an myocardial infarction in the CARE trial.
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Figure 4 (A) The overall effect of the combination of age and left ventricular ejection fraction (LVEF) on the rate of hospitalizations for heart failure (HF) over a mean follow-up of five years in the CARE population. (B) The overall effect of the combination of age and LVEF on the rate of hospitalizations for HF and death over a mean follow-up of five years in the CARE population.
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