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Addition of paclitaxel to contrast media prevents restenosis after coronary stent implantation

Bruno Scheller, MD^*,*, Ulrich Speck, PhD, Alexander Schmitt^*, Michael Böhm, MD^* and Georg Nickenig, MD^*

^* Internal Medicine III (Cardiology/Angiology), University of Saarland, Homburg/Saar, Germany
Department of Radiology, Humboldt University, Charité, Berlin, Germany

View larger version (39K): [in a new window]   Figure 1 Effects of different concentrations and incubation times (60, 10, and 3 min) of iopromide (75 mg/ml iodine) or iopromide plus paclitaxel (1.46 or 14.6 µmol/l) as the final concentration in the cell culture medium. Bovine aortic smooth muscle cells (passages 3 to 10) were seeded at 10,000/cm2, cultured with DMEM plus 10% FBS; cell counts were taken on days 0, 3, 6, 9 and 12. *p < 0.05 vs. control; n = 50.

View larger version (41K): [in a new window]   Figure 2 Histologic analysis of stented porcine coronary arteries after 28 days. Control (left), 100 µmol/l intracoronary iopromide paclitaxel (middle), and 200 µmol/l intracoronary iopromide paclitaxel (right). Stented coronary arteries were dissected from the formalin-fixed hearts, immersed in methylmethacrylate, and separated from the blocks with a coping saw, polished, and glued on acrylic plastic slides. Specimens were stained by the hematoxylin-eosin technique.