This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Guazzi, M. Articles by Guazzi, M. D. Search for Related Content PubMed PubMed Citation Articles by Guazzi, M. Articles by Guazzi, M. D.

Insulin ameliorates exercise ventilatory efficiency and oxygen uptake in patients with heart failure–type 2 diabetes comorbidity

Marco Guazzi, MD, PhD, FACC^*,*, Gabriele Tumminello, MD^*, Marco Matturri, MD and Maurizio D. Guazzi, MD, PhD

^* Department of Medicine and Surgery, University of Milan, Cardiology Division, San Paolo Hospital, Milan, Italy
Institute of Cardiology, University of Milan, Milan, Italy

View larger version (28K): [in a new window]   Figure 1 Individual responses to insulin of the pulmonary gas exchange and exercise capacities. Filled circles are the means ± SD. *p < 0.01 vs. baseline. DLCO = lung diffusing capacity for carbon monoxide; DM = diffusing capacity of the alveolar-capillary membrane; peak VO2 = oxygen consumption at peak exercise; Vc = pulmonary capillary volume available for gas exchange; VE/VCO2 slope = slope of the increase in ventilation with respect to carbon dioxide production; VO2AT = oxygen consumption at the anaerobic threshold.

View larger version (10K): [in a new window]   Figure 2 Individual changes in carbon monoxide diffusion (DLCO) vs. changes in peak exercise oxygen uptake (peak VO2) and in the slope of increase in ventilation with respect to carbon dioxide production (VE/VCO2 slope), after insulin infusion.