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Pleiotropic effects of angiotensin II receptor blocker in hypertensive patients

Kwang Kon Koh, MD, FACC^*,*, Jeong Yeal Ahn, MD, Seung Hwan Han, MD^*, Dae Sung Kim, MD, Dong Kyu Jin, MD^*, Hyung Sik Kim, MD, Mi-Seung Shin, MD^*, Tae Hoon Ahn, MD^*, In Suck Choi, MD^* and Eak Kyun Shin, MD^*

^* Departments of Cardiology, Gachon Medical School, Incheon, South Korea
Clinical Pathology, Gachon Medical School, Incheon, South Korea
Radiology, Gachon Medical School, Incheon, South Korea
Preventive Medicine (Biostatistics), Gachon Medical School, Incheon, South Korea

View larger version (24K): [in a new window]   Figure 1 Compared with placebo, candesartan therapy significantly lowered plasma levels of monocyte chemoattractant protein-1 from the respective baseline levels (p = 0.003). Open circles = mean values.

View larger version (20K): [in a new window]   Figure 2 Compared with placebo, candesartan therapy significantly lowered plasma levels of plasminogen activator inhibitor type-1 (PAI-1) from the respective baseline levels (p < 0.001). Open circles = mean values.